Using different settings for Color Management will result in different input colors that you see with your eyes in the RGB input node even if is the same color code, for example, FF0000
This can be confusing but also can drive to mistakes, because you may think that is something but is something else instead.
Please consult the image and video demonstration.
In the below image, both examples use the same color code: FF0000,
https://youtu.be/LuwhNC2N-cE


