System Information
Operating system: Windows 10 1903
Graphics card: 1050 ti
Using an XP-Pen Tablet (Star G-640) (Don't think that matters)

Blender Version
Broken: Blender quits
Worked: Blender 2.8

Short description of error
Ctrl + Num+ close the whole blender window leaving no autosave behind.

Exact steps for others to reproduce the error
Open Blender.exe
New File> 2D Animation
Draw one or two strokes (Brush doesn't matter)
Click on the Dope Sheet and move to frame 2
Click Ctrl+Num+
Program Close without save

And I don't think that my drawing tablet matters, the error can be recreated even by a mouse.